Vol.13, No.1, February 2024.                                                                                                                                                                               ISSN: 2217-8309

                                                                                                                                                                                                                        eISSN: 2217-8333


TEM Journal



Association for Information Communication Technology Education and Science

Models of Irreversible Electroporation: A Review and Initial Model Implementation


Tihomir Georgiev, Kristina Bliznakova, Zhivko Bliznakov, Georgi Todorov


© 2024 Tihomir Georgiev, published by UIKTEN. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. (CC BY-NC-ND 4.0)


Citation Information: TEM Journal. Volume 13, Issue 1, Pages 524-530, ISSN 2217-8309, DOI: 10.18421/TEM131-54, February 2024.


Received: 20 October 2023.

Revised:   02 February 2024.
Accepted: 07 February 2024.
Published: 27 February 2024.




Cancer may affect any person. Amongst possible techniques to treat some cancers is ablation, through the use of the irreversible electroporation (IRE) as one of the methods. Medical University of Varna is implementing a project on irreversible electroporation aiming to develop a hardware prototype. The first step is review of existing models and the development of an own model, which will be used in the device prototyping. To find the existing models, we reviewed articles related to electroporation models. Based on the literature review, we developed own model, where we used open-source software OpenEP and Embarcadero C++. The review of the available literature publications indicates that initial models employed a simplified cell structure. Despite this simplicity, these models effectively reflected important characteristics of the cell behaviour and the interdependencies between field features and cells. Recent investigations created better models and optimized parameters for specific cases. The review models were used in the development of dedicated software application for simulation, visualization, and educational purposes in the field of IRE. Developed software application allows investigation of various IRE protocols. Experimental investigation of implemented models and software is undergoing. The software will allow further advancement in our capacity to explore and comprehend cellular dynamics.


Keywords –Electroporation models, irreversible electroporation models, software application, pore density.



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