Vol.7, No.4, November 2018.                                                                                                                                                                             ISSN: 2217-8309

                                                                                                                                                                                                                        eISSN: 2217-8333


TEM Journal



Association for Information Communication Technology Education and Science

Identification of 677C>T Polymorphism of LRP1 Gene by PCR-RFLP Method


Amela Jusić, Aldijana Avdić, Vesna Hadžiavdić, Inela Junuzović, Dženita Kurtčehajić


© 2018 Amela Jusić, published by UIKTEN. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. (CC BY-NC-ND 4.0)


Citation Information: TEM Journal. Volume 7, Issue 4, Pages 803-807, ISSN 2217-8309, DOI: 10.18421/TEM74-17, November 2018.


Received: 21 August 2018.
Accepted: 19 October 2018.
Published: 26 November 2018.




The 677 C>T (rs1799986) polymorphism is located at position 677 in exon 3 of the LRP1 gene. The aim of this study was to determine the allele and
genotype frequencies of the polymorphism in Bosnian population. The study included 100 unrelated healthy individuals. Genotyping of 677 C>T polymorphism of
the LRP1 gene was performed with PCR-RFLP method. The most frequent allele was the C allele (91%), while the T allele was represented by 9%. These
results suggested that presence of the 677 C>T polymorphism of the LRP1 gene in our population should be a base for further case-control association or
population genetics studies.


Keywords –LRP1 gene, PCR-RFLP method.



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